{"id":1244,"date":"2024-08-13T12:24:17","date_gmt":"2024-08-13T12:24:17","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=1244"},"modified":"2024-09-13T12:28:32","modified_gmt":"2024-09-13T12:28:32","slug":"nathalie-ollivier","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/nathalie-ollivier\/","title":{"rendered":"Nathalie Ollivier CV"},"content":{"rendered":"\n
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+33 (0)3 20 87 12 16<\/p><\/div>\n\n\n\n

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Nathalie.Ollivier@ibl.cnrs.fr<\/p><\/div>\n<\/div>\n\n\n\n

Date of birth : 05\/07\/1975 ; Nationality : French<\/p>\n\n\n

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Researcher unique identifier : ORCID 0000-0001-8870-5635<\/a><\/p>\n\n\n\n

I am at the forefront of innovation in the lab to discover new chemical ligation reactions for protein synthesis and modification.  <\/p>\n\n\n\n

I set up the development of SEA chemistry and did the total chemical synthesis of proteins under redox control. (Org. Lett. 2010 <\/strong>DOI<\/a> , <\/strong>Angewandte Chemie Int. Ed. 2012 <\/strong>DOI<\/a> , <\/strong>J. Pep. Sci.<\/em> 2013 <\/strong>DOI<\/a> ).<\/strong><\/p>\n\n\n\n

I participated in the understanding of hepatocyte growth factor\/MET receptor activation determinants by chemically producing the kringle 1 domain of HGF\/SF, the ligand of MET receptor. (Angewandte Chemie Int. Ed. 2012 <\/strong>DOI<\/a>, <\/strong>J., Chem. Sci 2015 <\/strong>DOI<\/a> ). <\/strong>The design of a strong MET agonist is currently in progress for regenerative medicine, in collaboration with E. Gherardi\u2019s team in Pavia, Italy.<\/p>\n\n\n\n

EDUCATION<\/strong><\/strong><\/p>\n\n\n\n

1998 – Master in Organic Chemistry. University of Haute-Alsace, Mulhouse, France.<\/p>\n\n\n\n

1998 – Engineer from Ecole Nationale Sup\u00e9rieure de Chimie de Mulhouse, France.<\/p>\n\n\n\n

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CURRENT<\/strong> <\/strong>P<\/strong>O<\/strong>SI<\/strong>T<\/strong>I<\/strong>ON<\/strong><\/strong><\/p>\n\n\n\n

Since 2006 – Research Engineer, Pasteur Institute of Lille, France.<\/p>\n\n\n\n

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PREVIOUS POSITION<\/p>\n\n\n\n

1998-2006 – Studies Engineer, Pasteur Institute of Lille, France.<\/p>\n\n\n\n

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SELECTION OF FIVE RECENT PUBLICATIONS<\/strong><\/p>\n\n\n\n

1<\/strong><\/td>Ollivier, N.; Roy, E.; Desmet, R.; Agouridas, V.; Diemer,V.; Melnyk, O. (2023). Electrostatic Assistance of 4-Mercaptophenylacetic acid Catalyzed Native Chemical Ligation. Org. Lett.,<\/em> 25, 15, 2696-2700. DOI<\/a>
We achieved accelerations for peptide bond formation using lower catalyst loading by engineering electrostatic interactions between the catalyst and the peptide reactants.<\/em><\/td><\/tr>
2<\/strong><\/td>Agouridas, V.; Ollivier, N.; Vicogne, J.; Diemer, V.; Melnyk, O. (2022). Redox-controlled chemical protein synthesis: sundry shades of latency. Acc. Chem. Res<\/em>., 55, 2685-2697. DOI<\/a>
An account of our work on the chemical synthesis of proteins using redox controlled chemical systems.<\/em>  <\/em><\/td><\/tr>
3<\/strong><\/td>Ollivier, N.\u00a0; S\u00e9n\u00e9chal, M.\u00a0; Desmet, R.\u00a0; Snella, B.\u00a0; Agouridas, V.\u00a0; and Melnyk, O. (2022). A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification. Nat. Commun. 13<\/em>, 6667. DOI<\/a>
We achieved outstanding accelerations for peptide bond formation by engineering electrostatic interactions in the peptide reactants.<\/em>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td><\/tr>
4<\/strong><\/td>Diemer, V. ; Ollivier, N. ; Leclercq, B. ; Drobecq, H. ; Vicogne, J. ; Agouridas, V. ; Melnyk, O. (2020). A cysteine selenosulfide redox switch for protein chemical synthesis. Nat. Commun.<\/em> 11<\/em>, 2558. DOI<\/a>
We designed a redox-controlled cysteine surrogate facilitating the chemical synthesis of complex protein scaffolds such as cyclic proteins. Article highlighted by the Editors of Nature Communications.<\/em><\/td><\/tr>
5<\/strong><\/td>Ollivier, N. ; Toupy, T. ; Hartkoorn, R.C. ; Desmet, R. ; Monbaliu, J.C.M. ; Melnyk, O. (2018). Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides. Nat. Commun.<\/em>, 9, 2847. DOI<\/a>
We designed a microfluidic system which enables cyclisation of peptides at difficult junctions in a few minutes.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Date of birth : 05\/07\/1975 ; Nationality : French Researcher unique identifier : ORCID 0000-0001-8870-5635 I am at the forefront of innovation in the lab to discover new chemical ligation reactions for protein synthesis and modification.   I set up the development of SEA chemistry and did the total chemical synthesis of proteins under redox control. (Org. Lett. 2010… Read More »Nathalie Ollivier CV<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/1244"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=1244"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/1244\/revisions"}],"predecessor-version":[{"id":1368,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/1244\/revisions\/1368"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=1244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}