{"id":1302,"date":"2024-09-13T10:51:57","date_gmt":"2024-09-13T10:51:57","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=1302"},"modified":"2024-09-13T12:11:41","modified_gmt":"2024-09-13T12:11:41","slug":"alexandra-mougel","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/alexandra-mougel\/","title":{"rendered":"Alexandra mougel CV"},"content":{"rendered":"\n
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+33 (0)3 20 87 12 45<\/p><\/div>\n\n\n\n

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alexandra.mougel@ibl.cnrs.fr<\/p><\/div>\n<\/div>\n\n\n\n

Date of birth : 1972 ; Nationality : French<\/p>\n\n\n

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My research activity is focussed on the study of receptor tyrosine kinases in model invertebrates for their role in development and reproduction.<\/p>\n\n\n\n

EDUCATION<\/strong><\/strong><\/p>\n\n\n\n

1997 – M. Sc Research, Molecular Biology and Immunology, University of Lille, France.<\/p>\n\n\n\n

1994 – B. Sc, Molecular Biology and Cellular, University of Lille, France.<\/p>\n\n\n\n

1993 – Superior Technician Degree in biological analysis, Nancy, France.<\/p>\n\n\n\n

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CURRENT<\/strong> <\/strong>P<\/strong>O<\/strong>SI<\/strong>T<\/strong>I<\/strong>ON<\/strong><\/strong><\/p>\n\n\n\n

Since 2017 – CNRS Research Engineer (IEHC)<\/p>\n\n\n\n

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PREVIOUS POSITION<\/p>\n\n\n\n

2008-2017 – CNRS Research Engineer (IE1), UMR 8161 CNRS.<\/p>\n\n\n\n

1998-2008 – CNRS Research Engineer (IE2), UMR 8527 CNRS.<\/p>\n\n\n\n

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SELECTION OF FIVE RECENT PUBLICATIONS<\/strong><\/p>\n\n\n\n

1<\/strong><\/td>Mouton, Stijn, Alexandra Mougel, Kirill Ustyantsev, Colette Dissous, Oleg Melnyk, Eugene Berezikov, et J\u00e9r\u00f4me Vicogne. \u00ab Optimized protocols for RNA interference in Macrostomum lignano \u00bb. G3 Genes|Genomes|Genetics<\/em> 2024, 14, jkae037. https:\/\/doi.org\/10.1093\/g3journal\/jkae037<\/a>.
Using our expertise in Schistosoma mansoni biology, we developed a cost-effective method for genetic interference in the flatworm Macrostomum lignano.<\/em><\/td><\/tr>
2<\/strong><\/td>Nola, Giovanni de, B\u00e9r\u00e9nice Leclercq, Alexandra Mougel, Solenne Taront, Claire Simonneau, Federico Forneris, Eric Adriaenssens, et al. \u00ab Dimerization of kringle 1 domain from hepatocyte growth factor\/scatter factor provides a potent MET receptor agonist \u00bb. Life Sci. Alliance<\/em> 2022, 5: e202201424. https:\/\/doi.org\/10.26508\/lsa.202201424<\/a>.
Using combinations of chemical and structural biology approaches, we designed of a potent c-MET agonist with broad applications in regenerative medicine.<\/em><\/td><\/tr>
3<\/strong><\/td>Mougel, Alexandra, Eric Adriaenssens, Boris Guyot, Lu Tian, St\u00e9phanie Gobert, Thierry Chassat, Philippe Persoons, et al. \u00ab Macrophage-Colony-Stimulating Factor Receptor Enhances Prostate Cancer Cell Growth and Aggressiveness In Vitro and In Vivo and Increases Osteopontin Expression \u00bb. International Journal of Molecular Sciences<\/em> 2022, 23: 16028. https:\/\/doi.org\/10.3390\/ijms232416028<\/a>.
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4<\/strong><\/td>Leippe, P., J. Broichhagen, K. Cailliau, A. Mougel, M. Morel, C. Dissous, D. Trauner, et J. Vicogne. \u00ab Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors \u00bb. Angew. Chem. Int. Ed.<\/em> 2020, 59: 6720\u201123. https:\/\/doi.org\/10.1002\/anie.201915352<\/a>.
By mimicking the natural structure of the Venus Kinase Receptor and taking advantages photo-switchable glutamate ligands, we generate photo-activatable humanized tyrosine kinase chimeras<\/em>.
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5<\/strong><\/td>Mekki, M. S., A. Mougel, A. Vinchent, C. Paquet, M. C. Copin, C. Leroy, Z. Kherrouche, et al. \u00ab Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors \u00bb. Oncotarget<\/em> 2018, 9: 27039\u201158. https:\/\/doi.org\/10.18632\/oncotarget.25472<\/a>.<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Date of birth : 1972 ; Nationality : French My research activity is focussed on the study of receptor tyrosine kinases in model invertebrates for their role in development and reproduction. EDUCATION 1997 – M. Sc Research, Molecular Biology and Immunology, University of Lille, France. 1994 – B. Sc, Molecular Biology and Cellular, University of Lille, France. 1993… Read More »Alexandra mougel CV<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/1302"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=1302"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/1302\/revisions"}],"predecessor-version":[{"id":1356,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/1302\/revisions\/1356"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=1302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}