{"id":618,"date":"2024-02-14T13:35:35","date_gmt":"2024-02-14T13:35:35","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=618"},"modified":"2024-02-14T14:03:21","modified_gmt":"2024-02-14T14:03:21","slug":"porfolio3","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/porfolio3\/","title":{"rendered":"Porfolio 3"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-medium-font-size\">Oxalyl thioesters are cell metabolites endowed with remarkably powerful acyl transfer abilities. The present article describes the bioinspired design of stable and activatable oxalyl thioester surrogates and their application for the modification of peptides and proteins. Formation of a stable oxalamide crosslink proceeds at rates ~30 M<sup>-1<\/sup> s<sup>-1<\/sup>, in the nanomolar concentration range, in purified media or in protein extracts of cell lysates.<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><em>Selected as a Hot Paper by the journal<\/em>.<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-nv-c-1-color\"><a href=\"https:\/\/doi.org\/10.1002\/anie.202204992\">Link to the article<\/a><\/mark><\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"591\" height=\"558\" src=\"https:\/\/mint-team.fr\/wp-content\/uploads\/2024\/02\/Fmoc-LysoxoSEA.jpg\" alt=\"\" class=\"wp-image-620\" style=\"width:500px\" srcset=\"https:\/\/mint-team.fr\/wp-content\/uploads\/2024\/02\/Fmoc-LysoxoSEA.jpg 591w, https:\/\/mint-team.fr\/wp-content\/uploads\/2024\/02\/Fmoc-LysoxoSEA-300x283.jpg 300w\" sizes=\"(max-width: 591px) 100vw, 591px\" \/><\/figure><\/div>","protected":false},"excerpt":{"rendered":"<p>Oxalyl thioesters are cell metabolites endowed with remarkably powerful acyl transfer abilities. The present article describes the bioinspired design of stable and activatable oxalyl thioester surrogates and their application for the modification of peptides and proteins. Formation of a stable oxalamide crosslink proceeds at rates ~30 M-1 s-1, in the nanomolar concentration range, in purified&hellip;&nbsp;<a href=\"https:\/\/mint-team.fr\/index.php\/porfolio3\/\" class=\"\" rel=\"bookmark\">Read More &raquo;<span class=\"screen-reader-text\">Porfolio 3<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/618"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=618"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/618\/revisions"}],"predecessor-version":[{"id":644,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/618\/revisions\/644"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}