{"id":751,"date":"2024-04-08T07:36:33","date_gmt":"2024-04-08T07:36:33","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=751"},"modified":"2024-10-01T11:56:40","modified_gmt":"2024-10-01T11:56:40","slug":"oleg-melnyk","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/oleg-melnyk\/","title":{"rendered":"Dr Oleg Melnyk CV"},"content":{"rendered":"
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+33 (0)3 20 87 12 14<\/p><\/div>\n\n\n\n

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oleg.melnyk@ibl.cnrs.fr<\/p><\/div>\n<\/div>\n\n\n\n

Date of birth: 03\/27\/1966; Nationality: French <\/p>\n\n\n\n

Researcher unique identifier: ORCID 0000-0002-3863-5613<\/a><\/p>\n\n\n\n

Contribution to synthetic organic chemistry: <\/strong>I pioneered the development of reversible amides acting as acyl donors in water and enabling the total chemical synthesis of proteins under redox control (Chem. Rev. 2019 <\/strong>DOI<\/strong><\/a>, Curr. Opin. Chem. Biol. 2020 <\/strong>DOI<\/strong><\/a>, Acc. Chem. Res. 2022 <\/strong>DOI<\/strong><\/a>, co-foundation of XProChem<\/strong><\/a>).<\/p>\n\n\n\n

Contribution to chemical biology & protein therapeutic design: <\/strong>I contributed to the understanding of hepatocyte growth factor\/MET receptor activation determinants using chemical biology approaches. This knowledge enabled the design of a strong MET agonist currently developed for regenerative medicine, in collaboration with E. Gherardi\u2019s team in Pavia, Italy (Chem. Sci. 2015<\/strong> DOI<\/strong><\/a>, Life Sci. Alliance 2022 <\/strong>DOI<\/strong><\/a>)<\/p>\n\n\n\n

Contribution to micro-nanotechnologies: <\/strong>I contributed to the development of ligation chemistries enabling the synthesis of conjugates, the attachment of peptides to surfaces and the design of peptide\/protein-based micro-nanosystems (Bioconjugate Chem. 2004 <\/strong>DOI<\/strong><\/a>, Appl. Phys. Lett. 2004 <\/strong>DOI<\/strong><\/a>, co-foundation of Innobiochips<\/strong><\/a>)<\/p>\n\n\n\n

EDUCATION<\/strong><\/strong><\/p>\n\n\n\n

2000      Habilitation thesis to supervise research.<\/p>\n\n\n\n

1994      PhD \u201cTotal synthesis of cortisone\u201d<\/em>. University Pierre et Marie Curie, Paris, France.<\/p>\n\n\n\n

1989      Master \u00ab Organocuprate chemistry \u00bb<\/em>. University Pierre et Marie Curie, Paris, France.<\/p>\n\n\n\n

1989      Engineer from Ecole Nationale Sup\u00e9rieure de Chimie de Paris, France.<\/p>\n\n\n\n

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CURRENT<\/strong> <\/strong>P<\/strong>O<\/strong>SI<\/strong>T<\/strong>I<\/strong>ON<\/strong><\/strong><\/p>\n\n\n\n

Since 2006. Director of Research at CNRS working as team leader.<\/p>\n\n\n\n

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P<\/strong>REV<\/strong>I<\/strong>OU<\/strong>S POSITIONS<\/strong><\/p>\n\n\n\n

2002-2006           Team leader, Pasteur Institute of Lille, France<\/p>\n\n\n\n

1996-2002         CNRS researcher, Pasteur Institute of Lille, France<\/p>\n\n\n\n

1994-1996         Post-doc \u201cDesign of <\/em>b<\/em>-turn mimetics\u201d<\/em>, Pasteur Institute of Lille, France<\/p>\n\n\n\n

1990-1994           PhD at Roussel-Uclaf (now Sanofi), Romainville, France<\/p>\n\n\n\n

1989-1990           Engineer at the Central Commission of Nuclear Energy (CEA), Bruy\u00e8re-le-Chatel, France.<\/p>\n\n\n\n

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F<\/strong>ELLO<\/strong>W<\/strong>S<\/strong>H<\/strong>IP<\/strong>S AND AWARDS<\/strong><\/p>\n\n\n\n

2014                     Grand Valorization Prize received from the Soci\u00e9t\u00e9 Industrielle du Nord de France (SINF)<\/p>\n\n\n\n

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2013                      Innovation trophy from Institut National de la Propri\u00e9t\u00e9 Industrielle (INPI)<\/p>\n\n\n

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CREATION OF START-UPS<\/strong><\/strong><\/p>\n\n\n\n

2012      Co-founder of XProChem. http:\/\/xprochem.com\/fr\/<\/a><\/p>\n\n\n\n

2008      Co-founder of Innobiochips. http:\/\/www.innobiochips.fr\/<\/a><\/p>\n\n\n\n

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M<\/strong>E<\/strong>M<\/strong>BER<\/strong>S<\/strong>H<\/strong>I<\/strong>P<\/strong>S OF SCIENTIFIC SOCIETIES<\/strong><\/p>\n\n\n\n

Since 2021          Board member of the European Peptide Society (French representative)<\/p>\n\n\n\n

Since 2021          Board member of the French peptide & protein society (GFPP)<\/p>\n\n\n\n

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PARTICIPATION TO EDITORIAL BOARDS<\/strong><\/p>\n\n\n\n

Since 2022         Biopolymers<\/a><\/p>\n\n\n\n

Since 2013          International Journal of Peptide Therapeutics<\/a><\/p>\n\n\n\n

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SELECTION OF FIVE RECENT PUBLICATIONS<\/strong><\/p>\n\n\n\n

1<\/strong><\/td>Desmet, R., Boidin-Wichlacz, C., Mhidia, R., Tasiemski, A., Agouridas, V., and Melnyk, O. (2023). An Iron-Catalyzed Protein Desulfurization Method Reminiscent of Aquatic Chemistry. Angew. Chem. Int. Ed. 62. e202302648. DOI<\/a> A novel method for effecting the selective desulfurization of cysteine at the protein level, using an iron-catalyzed process reminiscent of aquatic chemistry. Hot Paper.<\/strong><\/em><\/td><\/tr>
2<\/strong><\/td>Ollivier, N., S\u00e9n\u00e9chal, M., Desmet, R., Snella, B., Agouridas, V., and Melnyk, O. (2022). A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification. Nat. Commun. 13<\/em>. 66667. DOI<\/a> We achieved outstanding accelerations for peptide bond formation by engineering electrostatic interactions in the peptide reactants.<\/em><\/td><\/tr>
3<\/strong><\/td>Snella, B.; Grain, B.; Vicogne, J.; Capet, F.; Melnyk, O.; Agouridas, V. (2022) Fast protein modification in the nanomolar concentration range using an oxalyl amide as latent thioester. Angew. Chem. Int. Ed.<\/em> 61<\/em>, e202204992. DOI<\/a> Inspired by the very high reactivity of some cell metabolites, this work has potentially significant implications for the accelerated production of conjugates of medical interest. Hot Paper.<\/strong><\/em><\/td><\/tr>
4<\/strong><\/td>Agouridas, V.; Ollivier, N.; Vicogne, J.; Diemer, V.; Melnyk, O.c Redox-controlled chemical protein synthesis: sundry shades of latency. Acc. Chem. Res. 2022, 55, 2685-2697. DOI<\/a> An account of our work on the chemical synthesis of proteins using redox controlled chemical systems.<\/em>  <\/em><\/td><\/tr>
5<\/strong><\/td>Diemer, V.; Ollivier, N.; Leclercq, B.; Drobecq, H.; Vicogne, J.; Agouridas, V.; Melnyk, O. (2020) A cysteine selenosulfide redox switch for protein chemical synthesis. Nat. Commun.<\/em> 11<\/em>, 2558. DOI<\/a> – W<\/em>e designed a redox-controlled cysteine surrogate facilitating the chemical synthesis of complex protein scaffolds such as cyclic proteins. Article highlighted by the Editors of Nature Communications.<\/strong><\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Date of birth: 03\/27\/1966; Nationality: French  Researcher unique identifier: ORCID 0000-0002-3863-5613 Contribution to synthetic organic chemistry: I pioneered the development of reversible amides acting as acyl donors in water and enabling the total chemical synthesis of proteins under redox control (Chem. Rev. 2019 DOI, Curr. Opin. Chem. Biol. 2020 DOI, Acc. Chem. Res. 2022 DOI,… Read More »Dr Oleg Melnyk CV<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/751"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=751"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/751\/revisions"}],"predecessor-version":[{"id":1405,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/751\/revisions\/1405"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}