{"id":792,"date":"2024-04-08T10:14:50","date_gmt":"2024-04-08T10:14:50","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=792"},"modified":"2024-04-15T12:06:15","modified_gmt":"2024-04-15T12:06:15","slug":"dr-jerome-vicogne","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/dr-jerome-vicogne\/","title":{"rendered":"Dr JEROME vicogne CV"},"content":{"rendered":"
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+33 (0)320 87 12 49<\/p><\/div>\n\n\n\n

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jerome.vicogne@ibl.cnrs.fr<\/p><\/div>\n<\/div>\n\n\n\n

Date of birth: 08\/28\/1977; Nationality: French <\/p>\n\n\n\n

Researcher unique identifier: ORCID 0000-0001-8360-7497<\/a><\/p>\n\n\n\n

Contribution to schistosomiasis: <\/strong>I discovered the Venus Receptor Kinase (VKR) family in the parasite Schistosoma mansoni<\/em> and studied their role in its reproduction and development. I developed the first microfluidic devices for studying parasite in dynamic and biomimetic environment (Mol. Biol. Parasitol. 2003 <\/strong>DOI<\/strong><\/a>, J. Biol. Chem 2004 <\/strong>DOI<\/strong><\/a>, R. Soc. Open Sci.DOI<\/strong><\/a>).<\/p>\n\n\n\n

Contribution to chemical biology & protein therapeutic design: <\/strong>I contributed to the understanding of the HGF\/SF-MET receptor activation determinants using chemical biology and biophysical approaches in collaboration with E. Gherardi\u2019s team in Pavia (Italy). This knowledge enabled the design of a strong MET agonist (K1K1) with a broad field of applications in regenerative medicine. I am supervising its industrial development with the pharmaceutical company Boehringer Ingelheim International (Chem. Sci. 2015<\/strong> DOI<\/strong><\/a>, Life Sci. Alliance 2022 <\/strong>DOI<\/strong><\/a>, Dev. Growth Diff. 2022<\/strong> DOI<\/strong><\/a>)<\/p>\n\n\n\n

EDUCATION<\/strong><\/strong><\/p>\n\n\n\n

2022      Qualification for \u201cTeam management:\u201d. Pasteur Institute of Lille, 8 specific modules and workshops \u201cfrom individual to collective management\u201d (N\u00e9om, Lyon), France.<\/p>\n\n\n\n

2011      Accreditation for Research Direction (HDR), University of Lille: \u201cReceptors Tyrosine Kinases: structural and functional approaches. Implications in metabolic diseases and oncogenesis\u201d, Lille University, France.<\/p>\n\n\n\n

2003      PhD \u00ab Receptors Tyrosine Kinases in the parasite Schistosoma mansoni \u00bb (option parasitology and molecular biology), Lille University, France.<\/p>\n\n\n\n

2000      Master \u00ab Biology and Health \u00bb option immunology, Lille University, France.<\/p>\n\n\n\n

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CURRENT<\/strong> <\/strong>P<\/strong>O<\/strong>SI<\/strong>T<\/strong>I<\/strong>ON<\/strong><\/strong><\/p>\n\n\n\n

Since 2022         Director of Research at CNRS working as group leader.<\/p>\n\n\n\n

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P<\/strong>REV<\/strong>I<\/strong>OU<\/strong>S POSITIONS<\/strong><\/p>\n\n\n\n

2009-2022         CNRS researcher, Pasteur Institute of Lille, France<\/p>\n\n\n\n

2007-2009          Post-doc \u201cDesign of sugar-based c-MET inhibitors\u201d<\/em>, UMR8161 CNRS, Institut de Biologie de Lille, France.<\/p>\n\n\n\n

2003-2007          Post-doc \u201cGlucose transporters: SNAREs driven membrane fusion mechanisms\u201d<\/em>, SUNY at Stony Brook, New York, USA.<\/p>\n\n\n\n

2000-2003           PhD at Center for Immunity and Parasite Biology (U547 INSERM), Institut Pasteur de Lille, France<\/p>\n\n\n\n

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F<\/strong>ELLO<\/strong>W<\/strong>S<\/strong>H<\/strong>IP<\/strong>S AND AWARDS<\/strong><\/p>\n\n\n\n

2011                     Grand Prize received from GEFLUC cancer foundation<\/p>\n\n\n\n

2000-2003           CNRS PhD Fellowship<\/p>\n\n\n\n

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SELECTION OF FIVE RECENT PUBLICATIONS<\/strong><\/p>\n\n\n\n

1<\/strong><\/td>Mouton S, Mougel A, Ustyantsev K, Dissous C, Melnyk O, Berezikov E, Vicogne J. (2024) Optimized protocols for RNA interference in Macrostomum lignano<\/em>. G3 (Bethesda). 2024.<\/em>  DOI<\/a> Using our expertise in Schistosoma mansoni <\/em>biology<\/em>, we developed a<\/em> <\/em>cost-effective method for genetic interference in the flatworm Macrostomum lignano.<\/strong><\/em><\/td><\/tr>
2<\/strong><\/td>Girod V, Houssier R, Sahmer K, Ghoris MJ, Caby S, Melnyk O, Dissous C, Senez V, Vicogne J. (2022) A self-purifying microfluidic system for identifying drugs acting against adult schistosomes. R. Soc. Open Sci. 2022.<\/em> DOI<\/a> W<\/em>e designed the<\/em> first microfluidic device allowing a fast selection of anti-schistosomicidal drugs <\/em>in dynamic conditions<\/em>.<\/em><\/td><\/tr>
3<\/strong><\/td>De Nola G, Leclercq B, Mougel A, Taront S, Simonneau C, Forneris F, Adriaenssens E, Drobecq H, Iamele L, Dubuquoy L, Melnyk O, Gherardi E, de Jonge H, Vicogne J. (2022) Dimerization of kringle 1 domain from HGF\/SF provides a potent MET receptor agonist. Life Sci. Alliance. 2022. <\/em>DOI<\/a> Using combinations of chemical and structural biology approaches, we designed of a potent c-MET agonist with broad applications in regenerative medicine.<\/em><\/td><\/tr>
4<\/strong><\/td>Snella B, Grain B, Vicogne J, Capet F, Melnyk O, Agouridas V. (2022) Fast protein modification in the nanomolar concentration range using an oxalyl amide as latent thioester. Angew. Chem. Int. Ed.<\/em> 2022. DOI<\/a> Inspired by the very high reactivity of some cell metabolites, this work has potentially significant implications for the accelerated production of conjugates of medical interest. <\/em>Hot Paper.<\/em><\/strong>  <\/em><\/td><\/tr>
5<\/strong><\/td>Leippe P, Broichhagen J, Cailliau K, Mougel A, Morel M, Dissous C, Trauner D, Vicogne J. (2020) Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors. Angew Chem. Int. Ed. 2020<\/em>. DOI<\/a> By mimicking the natural structure of the Venus Kinase Receptor and taking advantages photo-switchable glutamate ligands, we generate photo-activatable humanized tyrosine kinase chimeras<\/em>.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Date of birth: 08\/28\/1977; Nationality: French  Researcher unique identifier: ORCID 0000-0001-8360-7497 Contribution to schistosomiasis: I discovered the Venus Receptor Kinase (VKR) family in the parasite Schistosoma mansoni and studied their role in its reproduction and development. I developed the first microfluidic devices for studying parasite in dynamic and biomimetic environment (Mol. Biol. Parasitol. 2003 DOI,… Read More »Dr JEROME vicogne CV<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/792"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=792"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/792\/revisions"}],"predecessor-version":[{"id":1080,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/792\/revisions\/1080"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}