{"id":800,"date":"2024-04-08T10:26:06","date_gmt":"2024-04-08T10:26:06","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=800"},"modified":"2024-04-15T12:04:31","modified_gmt":"2024-04-15T12:04:31","slug":"dr-vincent-diemer","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/dr-vincent-diemer\/","title":{"rendered":"Dr Vincent Diemer CV"},"content":{"rendered":"
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+33 (0)3 20 87 12 17<\/p><\/div>\n\n\n\n

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vincent.diemer@ibl.cnrs.fr<\/p><\/div>\n<\/div>\n\n\n\n

Date of birth: 13\/04\/1979; Nationality: French <\/p>\n\n\n\n

Researcher unique identifier: 0000-0002-5735-4630<\/a><\/p>\n\n\n\n

My research focuses on the development of novel synthetic strategies that facilitates, in terms of rate and number of chemical steps, the access to biologically relevant proteins.<\/p>\n\n\n\n

I developped new cysteine surrogates that enable the total chemical synthesis of linear or cyclic proteins under redox control (Acc. Chem. Res. 2022<\/strong> DOI<\/a>, J. Org. Chem. 2022<\/strong> DOI<\/a>, Methods in Molecular Biology DOI<\/a>, Nat. Commun. 2020<\/strong> DOI<\/a>).<\/p>\n\n\n\n

I contributed to the design of catalytic approaches that accelerate the ligation of peptide segments in water. (Org. Lett. 2023<\/strong> DOI<\/a>, J. Org. Chem. 2018<\/strong> DOI<\/a>)<\/p>\n\n\n\n

EDUCATION<\/strong><\/strong><\/p>\n\n\n\n

2007      PhD \u201cSynthesis of zwitterionic biaryls for SAR in nonlinear optics\u201d<\/em>. University of Haute-Alsace, Mulhouse, France.<\/p>\n\n\n\n

2003      Master in Organic Chemistry. University of Haute-Alsace, Mulhouse, France.<\/p>\n\n\n\n

2003      Engineer\u2019s degree. Ecole Nationale Sup\u00e9rieure de Chimie de Mulhouse, France.<\/p>\n\n\n\n

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CURRENT<\/strong> <\/strong>P<\/strong>O<\/strong>SI<\/strong>T<\/strong>I<\/strong>ON<\/strong><\/strong><\/p>\n\n\n\n

Since 2018          CNRS researcher, Lille, France.<\/p>\n\n\n\n

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P<\/strong>REV<\/strong>I<\/strong>OU<\/strong>S POSITIONS<\/strong><\/p>\n\n\n\n

2016-2018           Post-doc in Dr O. Melnyk team \u201cTotal synthesis of cyclic proteins\u201d<\/p>\n\n\n\n

Lille, France<\/p>\n\n\n\n

2014-2015           Post-doc in Dr G. Guichard team \u201cOligoureas as new organocatalysts\u201d<\/em><\/p>\n\n\n\n

Bordeaux, France.<\/p>\n\n\n\n

2011-2014           Post-doc in Pr J. Clayden team \u201cDesign and synthesis of poly-Aib peptide helices\u201d<\/em><\/p>\n\n\n\n

Manchester, England.<\/p>\n\n\n\n

2008-2010           Post-doc in Dr F. Leroux team \u201cDevelopment of the ARYNE coupling\u201d<\/em><\/p>\n\n\n\n

Strasbourg, France.<\/p>\n\n\n\n

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SELECTION OF FIVE RECENT PUBLICATIONS<\/strong><\/p>\n\n\n\n

1<\/strong><\/td>Ollivier, N.; Roy, E.; Desmet, R.; Agouridas, V.; Diemer, V.; Melnyk, O. (2023) Electrostatic Assistance of 4-Mercaptophenylacetic Acid-Catalyzed Native Chemical Ligation. Org. Lett.<\/em> 25<\/em>, 15, 2696. DOI<\/a><\/strong> We achieved accelerations for peptide bond formation using lower catalyst loading by engineering electrostatic interactions between the catalyst and the peptide reactants.<\/em><\/td><\/tr>
2<\/strong><\/td>Firstova, O.; Melnyk, O.; Diemer, V. (2022). Thiol catalysis of selenosulfide bond cleavage by a triarylphosphine. J. Org. Chem.<\/em> 87<\/em>, 14, 9426. DOI<\/a> We discovered that selenosulfide bond in model peptide sequences are efficiently cleaved by water-soluble aromatic phosphines in the presence of thiol.<\/em><\/td><\/tr>
3<\/strong><\/td>Agouridas, V.; Ollivier, N.; Vicogne, J.; Diemer, V.; Melnyk, O. (2022) Redox-controlled chemical protein synthesis: sundry shades of latency. Acc. Chem. Res. 55, 2685. DOI<\/a> An account of our work on the chemical synthesis of proteins using redox controlled chemical systems.<\/em><\/td><\/tr>
4<\/strong><\/td>Diemer, V.; Ollivier, N.; Leclercq, B.; Drobecq, H.; Vicogne, J.; Agouridas, V.; Melnyk, O. (2020) A cysteine selenosulfide redox switch for protein chemical synthesis. Nat. Commun.<\/em> 11<\/em>, 2558. DOI<\/a> W<\/em>e designed a redox-controlled cysteine surrogate facilitating the chemical synthesis of complex protein scaffolds such as cyclic proteins. Article highlighted by the Editors of Nature Communications.<\/strong><\/em><\/td><\/tr>
5<\/strong><\/td>Cargo\u00ebt, M.; Diemer, V.; Snella, B.; Desmet, R.; Blanpain, A.; Drobecq, H.; Agouridas, V.; Melnyk O. (2018) Catalysis of thiol-thioester exchange by water-soluble alkyldiselenols applied to the synthesis of peptide thioesters and SEA-mediated ligation. J. Org. Chem.<\/em> 83<\/em>, 20, 12584. DOI<\/a> We designed novel water-soluble catalysts that accelerate key processes used in protein chemical synthesis, i.e., thiol-thioester exchange and amide bond formation reactions.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Date of birth: 13\/04\/1979; Nationality: French  Researcher unique identifier: 0000-0002-5735-4630 My research focuses on the development of novel synthetic strategies that facilitates, in terms of rate and number of chemical steps, the access to biologically relevant proteins. I developped new cysteine surrogates that enable the total chemical synthesis of linear or cyclic proteins under redox… Read More »Dr Vincent Diemer CV<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/800"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=800"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/800\/revisions"}],"predecessor-version":[{"id":1077,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/800\/revisions\/1077"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}