{"id":839,"date":"2024-04-09T10:26:11","date_gmt":"2024-04-09T10:26:11","guid":{"rendered":"https:\/\/mint-team.fr\/?page_id=839"},"modified":"2024-04-15T12:04:41","modified_gmt":"2024-04-15T12:04:41","slug":"dr-vangelis-agouridas","status":"publish","type":"page","link":"https:\/\/mint-team.fr\/index.php\/dr-vangelis-agouridas\/","title":{"rendered":"Dr Vangelis Agouridas CV"},"content":{"rendered":"
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+33 (0)3 20 87 12 15<\/p><\/div>\n\n\n\n

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vangelis.agouridas@ibl.cnrs.fr<\/p><\/div>\n<\/div>\n\n\n\n

Nationality: French <\/p>\n\n\n\n

Researcher unique identifier: ORCID 0000-0003-0911-1527<\/a><\/p>\n\n\n\n

My research activities are focused on the chemistry of peptide thioesters and the native chemical ligation reaction (NCL) for protein synthesis and modification. They are deployed from development to application, including a mechanistic understanding of the approaches developed.<\/p>\n\n\n\n

Methodological developments : <\/strong>discovery and optimization of ligation systems through the application of new chemical reactivities (Chem. Rev. 2019<\/strong> DOI<\/strong><\/a>, Angew. Chem. Int. Ed. 2022 <\/strong>DOI<\/strong><\/a>, Nat. Commun. 2022 <\/strong>DOI<\/strong><\/a>, Acc. Chem. Res. 2022<\/strong> DOI<\/strong><\/a>)<\/p>\n\n\n\n

Total chemical synthesis of proteins:<\/strong> validation of the robustness of the developed methods through the total synthesis of one or more large demonstrators, most often in connexion with a biological problem (Molecules 2021 <\/strong>DOI<\/strong><\/a>, Org. Lett. 2023 <\/strong>DOI<\/strong><\/a>).<\/p>\n\n\n\n

Development of bibliographic analysis tools and computational approaches:<\/strong> Development of decision support tools for protein synthesis (Bioorg. Med. Chem. 2017 <\/strong>DOI<\/strong><\/a>, <\/strong>creator and webmaster of the Protein Chemical Synthesis database PCS : pcs-db.fr<\/a>) and kinetics-based mechanistic analysis of ligation reactions (J. Org. Chem. 2018 <\/strong>DOI<\/strong><\/a>, Nat. Commun. 2020 <\/strong>DOI<\/strong><\/a>)<\/p>\n\n\n\n

I teach organic chemistry at Centrale Lille-ENSCL from bachelor to master degrees (this includes classical reactivity, reactivity of biomolecules, heterocyclic chemistry, enzymatic catalysis\u2026 for an overall volume of ~250 h \/ academic year).<\/p>\n\n\n\n

EDUCATION<\/strong><\/strong><\/p>\n\n\n\n

2021    Habilitation thesis to supervise research.<\/p>\n\n\n\n

2006    PhD \u201cDesign, synthesis and biological evaluation of fluorinated analogues of steroidal antiestrogens\u201d<\/em>, University Versailles Saint-Quentin, Versailles, France.<\/p>\n\n\n\n

2003    Master \u00ab Fluorinated analogues of Tamoxifen \u00bb<\/em>, University Versailles Saint-Quentin, Versailles, France.<\/p>\n\n\n\n

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CURRENT<\/strong> <\/strong>P<\/strong>O<\/strong>SI<\/strong>T<\/strong>I<\/strong>ON<\/strong><\/strong><\/p>\n\n\n\n

Since 2020 Assistant Professor at Centrale Lille-ENSCL, Lille, France<\/p>\n\n\n\n

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P<\/strong>REV<\/strong>I<\/strong>OU<\/strong>S POSITIONS<\/strong><\/p>\n\n\n\n

2009-2020      Assistant Professor at Ecole Nationale Sup\u00e9rieure de Chimie Lille, Lille, France<\/p>\n\n\n\n

2008-2009      Post-doc \u201cLead optimization of a drug candidate\u201d,<\/em> Facult\u00e9 de Pharmacie de Ch\u00e2tenay-Malabry, Paris XI, Paris, France<\/p>\n\n\n\n

2007-2008      Post-doc \u201cTotal synthesis of discodermolide analogues\u201d<\/em>, Facult\u00e9 de Pharmacie de Paris V, Paris, France<\/p>\n\n\n\n

2006-2007      Post-doc \u201cTotal synthesis of cytotrienin A\u201d<\/em>, Boston University, Boston, USA<\/p>\n\n\n\n

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SELECTION OF FIVE RECENT PUBLICATIONS<\/strong><\/p>\n\n\n\n

1<\/strong><\/td>Desmet, R., Boidin-Wichlacz, C., Mhidia, R., Tasiemski, A., Agouridas, V., and Melnyk, O. (2023). An Iron-Catalyzed Protein Desulfurization Method Reminiscent of Aquatic Chemistry. Angew. Chem. Int. Ed. 62. e202302648. DOI<\/a> A novel method for effecting the selective desulfurization of cysteine at the protein level, using an iron-catalyzed process reminiscent of aquatic chemistry. Hot Paper.<\/strong><\/em><\/td><\/tr>
2<\/strong><\/td>Ollivier, N., S\u00e9n\u00e9chal, M., Desmet, R., Snella, B., Agouridas, V., and Melnyk, O. (2022). A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification. Nat. Commun. 13<\/em>. 66667. DOI<\/a> We achieved outstanding accelerations for peptide bond formation by engineering electrostatic interactions in the peptide reactants.<\/em><\/td><\/tr>
3<\/strong><\/td>Snella, B.; Grain, B.; Vicogne, J.; Capet, F.; Melnyk, O.; Agouridas, V. (2022) Fast protein modification in the nanomolar concentration range using an oxalyl amide as latent thioester. Angew. Chem. Int. Ed.<\/em> 61<\/em>, e202204992. DOI<\/a> Inspired by the very high reactivity of some cell metabolites, this work has potentially significant implications for the accelerated production of conjugates of medical interest. Hot Paper.<\/strong><\/em><\/td><\/tr>
4<\/strong><\/td>Agouridas, V.; Ollivier, N.; Vicogne, J.; Diemer, V.; Melnyk, O. Redox-controlled chemical protein synthesis: sundry shades of latency. Acc. Chem. Res. 2022, 55, 2685-2697. DOI<\/a> An account of our work on the chemical synthesis of proteins using redox controlled chemical systems.<\/em>  <\/em><\/td><\/tr>
5<\/strong><\/td>Diemer, V.; Ollivier, N.; Leclercq, B.; Drobecq, H.; Vicogne, J.; Agouridas, V.; Melnyk, O. (2020) A cysteine selenosulfide redox switch for protein chemical synthesis. Nat. Commun.<\/em> 11<\/em>, 2558. DOI<\/a> – W<\/em>e designed a redox-controlled cysteine surrogate facilitating the chemical synthesis of complex protein scaffolds such as cyclic proteins. Article highlighted by the Editors of Nature Communications.<\/strong><\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Nationality: French  Researcher unique identifier: ORCID 0000-0003-0911-1527 My research activities are focused on the chemistry of peptide thioesters and the native chemical ligation reaction (NCL) for protein synthesis and modification. They are deployed from development to application, including a mechanistic understanding of the approaches developed. Methodological developments : discovery and optimization of ligation systems through the… Read More »Dr Vangelis Agouridas CV<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_themeisle_gutenberg_block_has_review":false,"_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/839"}],"collection":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/comments?post=839"}],"version-history":[{"count":2,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/839\/revisions"}],"predecessor-version":[{"id":1078,"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/pages\/839\/revisions\/1078"}],"wp:attachment":[{"href":"https:\/\/mint-team.fr\/index.php\/wp-json\/wp\/v2\/media?parent=839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}