Year of birth: 1973; Nationality: French
Researcher unique identifier: ORCID 0000-0002-0242-868X
I currently contribute to the identification and characterization of antimicrobial peptides (AMPs) for a better understanding of their biological role in neuro-immune and anti-infectious responses in humans and invertebrates (J. Immunol 2008 DOI ; Scientific Reports 2015 DOI ; Front Immuno. 2020 DOI).
I currently contribute to the development of antimicrobial peptides from extremophilic worms as novel antibiotics against multidrug-resistant bacteria causing infectious lung diseases.
I contributed to the characterization of coelomocytes and hemocytes in invertebrates. Doing so is a first step toward the understanding of immunological processes, in particular of the innate immune responses leading to the secretion of humoral factors such as antimicrobial peptidesin boby fluids. In addition, these cell types can also be markers of adaptation to environmental factors or global warming…(Mol. Life Sci. 2011 DOI;Sci Total Environ 2018 DOI; DCI 2024 DOI).
EDUCATION
2010 – PhD “Characterization and functional study of players in the leech nervous system immune response”. University of Lille (Univ. Lille).
CURRENT POSITION
Since 2018 – CNRS Research Engineer at the Center of Infection and Immunity of Lille (CIIL), CNRS UMR 9017, Pasteur Institute of Lille.
SELECTION OF FIVE RECENT PUBLICATIONS
| 1 | Casanova M., Maresca M., Poncin I., Point V., Olleik H, Boidin-Wichlacz C., Tasiemski A., Mabrouk K., Cavalier J-F, Canaan S. (2024) Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus. J. Biomed. Sci. DOI Arenicin-1 was the safest peptide with no toxicity towards human cells and no hemolytic activity, and the most active against M. abscessus growth, and a rapid membranolytic effect that kills M. abscessus |
| 2 | Boidin-Wichlacz C., Andersen A-C., Jouy N., Hourdez S., Tasiemski A. (2024). A single coelomic cell type is involved in both immune and respiratory functions of the coastal bioindicator annelid: Capitella C-Channel1 from the English Channel. Dev. Comp. Immunol. DOI Description to morpho-functionally the circulating coelomic cells of Capitella from the English Channel inhabiting the sulfide-rich mud in Roscoff Harbor. |
| 3 | Bruno, R., Boidin-Wichlacz, C., Melnyk, O., Zeppilli, D., Landon, C., Thomas, F., Cambon, M.A., Lafond, M., Mabrouk, K., Massol, F., Hourdez, S., Maresca, M., Jollivet, D., Tasiemski, A. (2023) The diversification of the antimicrobial peptides from marine worms is driven by environmental conditions, STOTEN. DOI First evidence of the influence of the abiotic environment (temperature, pH, etc.) on the selection of AMPs, their sequence, biological activity and structure. |
| 4 | Hourdez, S., Boidin-Wichlacz, C., Jollivet, D., Massol, F., Rayol, M.C., Bruno, R., Zeppilli, D., Thomas, F., Lesven, L., Billon, G., Duperron, S., Tasiemski, A. (2021) Investigation of Capitella spp. symbionts in the context of varying anthropic pressures: First occurrence of a transient advantageous epibiosis with the giant bacteria Thiomargarita sp. to survive seasonal increases of sulfides in sediments, STOTEN. DOI Adaptation to changes in habitat, based on a transient detoxifying symbiosis with a giant bacterium, which allows a species of coastal worm to survive temporarily lethal sulfidic conditions in nature. |
| 5 | Le Bloa S., Boidin-Wichlacz C., Cueff-Gauchard V., Rosa R.D., Cuvillier-Hot V., Durand L., Methou P., Pradillon F., Cambon-Bonavita M.A., Tasiemski A. (2020) Antimicrobial Peptides and Ectosymbiotic Relationships: Involvement of a Novel Type IIa Crustin in the Life Cycle of a Deep-Sea Vent Shrimp. Front. Immunol. DOI A novel and unusual AMP sequence from an extremophilic organism and its role in establishing a vital symbiosis during the life cycle of an endemic deep-sea invertebrate |