- 2019
| Agouridas, V.; El Mahdi, O.; Diemer, V.; Cargoët, M.; Monbaliu, J.-C. M.; Melnyk, O. Native Chemical Ligation and Extended Methods: Mechanisms,Catalysis, Scope, and Limitations. Chem. Rev. 2019, 119, 7328-7443. |
| Bouchenna, J.; Sénéchal, M.; Drobecq, H.; Vicogne, J.; Melnyk, O. Total Chemical Synthesis of All SUMO-2/3 Dimer Combinations. Bioconjugate Chem. 2019, 30, 2967-2973. |
| Bouchenna, J.; Sénéchal, M.; Drobecq, H.; Stankovic-Valentin, N.; Vicogne, J.; Melnyk, O. The Role of the Conserved SUMO-2/3 Cysteine Residue on Domain Structure Investigated Using Protein Chemical Synthesis. Bioconjugate Chem. 2019, 30, 2684-2696. |
- 2018
| Mekki, M. S.; Mougel, A.; Vinchent, A.; Paquet, C.; Copin, M. C.; Leroy, C.; Kherrouche, Z.; Bonte, J. P.; Melnyk, O.; Vicogne, J.; Tulasne, D. Hypoxia leads to decreased autophosphorylation of the MET receptor and promotes its resistance to tyrosine kinase inhibitors. Oncotarget 2018, 9, 27039-27058. |
| Ollivier, N.; Toupy, T.; Haartkorn, R. C.; Desmet, R.; Monbaliu, J.-C. M.; Melnyk, O. Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides. Nat. Commun. 2018, 9, 2847 |
| Cargoët, M.; Diemer, V.; Snella, B.; Desmet, R.; Blanpain, A.; Drobecq, H.; Agouridas, V.; Melnyk O. Catalysis of Thiol–Thioester Exchange by Water-Soluble Alkyldiselenols Applied to the Synthesis of Peptide Thioesters and SEA-Mediated Ligation. J. Org. Chem. 2018, 83, 12584-12594 |
| Snella, B.; Diemer, V.; Drobecq, H.; Agouridas, V.; Melnyk, O. Native Chemical Ligation at Serine revisited. Org. Lett. 2018, 20, 7616-7619 |
| Cuvillier-Hot, V.; Gaudron, S. M.; Massol, F.; Boidin-Wichlacz, C.; Pennel, T.; Lesven, L.; Net, S.; Papot, C.; Ravaux, J.; Vekemans, X.; Billon, G.; Tasiemski, A. Immune failure reveals vulnerability of populations exposed to pollution in the bioindicator species Hediste diversicolor. STOTEN 2018, 613-614, 1527-1542. |
- 2017
| Papot, C.; Massol, F.; Jollivet, D.; Tasiemski, A. Antagonistic evolution of an antibiotic and its molecular chaperone: How to maintain a vital ectosymbiosis in a highly fluctuating habitat. Scientific Reports 2017, 7, 1454. |
| Agouridas, V.; El Mahdi, O.; Cargoët, M.; Melnyk, O. A statistical view of protein chemical synthesis using NCL and extended methodologies. Bioorg. Med. Chem. 2017, 25, 4938-4945 |
| Ollivier, N.; Desmet, R.; Drobecq, H.; Blanpain, A.; Boll, E.; Leclercq, B.; Mougel, A.; Vicogne, J.; Melnyk, O. A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins. Chem. Sci. 2017, 8, 5362-5370 |
| Gratzer, K.; Diemer, V.; Clayden, J. Signal transduction in oligoamide foldamers by selective non-covalent binding of chiral phosphates at a urea binding site. Org. Biomol. Chem. 2017, 15, 3585-3589. |
| Bécart, D.; Diemer, V.; Salaün, A.; Oiarbide, M.; Reddy Nelli, Y.; Kauffmann, B.; Fischer, L.; Palomo, C.; Guichard, G. Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C-C Bond Forming Reactions J. Am. Chem. Soc. 2017, 139, 12524-12532. |
| Diemer, V.; Maury, J.; Le Bailly, B. A. F.; Webb, S. J.; Clayden, J. Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers. Chem. Commun. 2017, 53, 10768-10771. |
- 2016
| Melnyk, O.; Vicogne, J. Total chemical synthesis of SUMO proteins. Tetrahedron Lett. 2016, 57, 4319-4324 |
| Boll, E.; Drobecq, H.; Lissy, E.; Cantrelle, F.-X.; Melnyk, O. Kinetically Controlled Chemoselective Cyclization Simplifies the Access to Cyclic and Branched Peptides. Org. Lett. 2016, 18, 3842-3845 |
| Drobecq, H.; Boll, E.; Sénéchal, M.; Desmet, R.; Saliou, J.-M.; Lacapère, J.-J.; Mougel, A.; Vicogne, J.; Melnyk O. A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide-Protein Conjugates. Bioconjugate Chem. 2016, 27, 1540-1546 |
| Raibaut, L.; Cargoët, M.; Ollivier, N.; Chang, Y. M.; Drobecq, H.; Boll, E.; Desmet, R.; Monbaliu, J.-C. M.; Melnyk O. Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates. Chem. Sci. 2016, 7, 2657-2665 |
| Pira, S. L.; El Mahdi, O.; Raibaut, L.; Drobecq, H.; Dheur, J.; Boll, E.; Melnyk O. Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH. Org. Biomol. Chem. 2016, 14, 7211-7216 |
| Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers. Jones, J. E., Diemer, V.; Adam C.; Raftery, J.; Ruscoe, R. E.; Sengel, J. T.; Wallace, M. I.; Bader, A.; Cockroft, S. L.; Clayden, J.; Webb, S. J. J. Am. Chem. Soc. 2016, 138, 688-695. |
| Diemer, V.; Fischer, L.; Kauffmann, B.; Guichard, G. Anion Recognition by Aliphatic Helical Oligoureas. Chemistry 2016, 22, 15684-15692. |
- 2015
| Raibaut, L.; El Mahdi, O.; Melnyk, O. Solid phase protein chemical synthesis. Top. Curr. Chem. 2015, 363, 154 |
| Raibaut, L.; Drobecq, H.; Melnyk, O. Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds. Org. Lett. 2015, 17, 3636-3639 |
| Tasiemski, A.; Rodet, F.; Boidin-Wichlacz, C.; Vuillaume, C.; Slomianny, C.; Salzet, M. Hm-MyD88 and Hm-SARM : two key regulators of the neuroimmune system and neural repair in the medicinal leech. Sci. Rep. 2015, 5, 9624. |
| Tasiemski, A.; Massol, F.; Cuvillier, V.; Boidin-Wichlacz, C.; Roger, E.; Rodet, F.; Fournier, I.; Thomas, F.; Salzet, M. Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii. Sci. Rep. 2015, 5, 17498 |
| Desmet, R.; Pauzuolis, M.; Boll, E.; Drobecq, H.; Raibaut, L.; Melnyk, O. Synthesis of Unprotected Linear or Cyclic O-Acyl Isopeptides in Water Using Bis(2-sulfanylethyl)amido Peptide Ligation. Org. Lett. 2015, 17, 3354-3357 |
| Simonneau, C.; Leclercq, B.; Mougel, A.; Adriaenssens, E.; Paquet, C.; Raibaut, L.; Ollivier, N.; Drobecq, H.; Marcoux, J.; Cianférani, S.; Tulasne, D.; De Jonge, H.; Melnyk, O.; Vicogne, J. Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist. Chem. Sci. 2015, 6, 2110-2121 |
| Boll, E.; Ebran, J.-P.; Drobecq H.; El-Mahdi O.; Raibaut L.; Ollivier N.; Melnyk O. Access to Large Cyclic Peptides by a One-Pot Two-Peptide Segment Ligation/Cyclization Process. Org. Lett. 2015, 17, 130-133 |
| Boll, E.; Drobecq, H.; Ollivier, N.; Blanpain, A.; Raibaut, L.; Desmet, R.; Vicogne, J.; Melnyk, O. One-pot chemical synthesis of small ubiquitin-like modifier protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates. Nat. Protocols 2015, 10, 269-292 |