Date of birth : 1972 ; Nationality : French
My research activity is focussed on the study of receptor tyrosine kinases in model invertebrates for their role in development and reproduction.
EDUCATION
1997 – M. Sc Research, Molecular Biology and Immunology, University of Lille, France.
1994 – B. Sc, Molecular Biology and Cellular, University of Lille, France.
1993 – Superior Technician Degree in biological analysis, Nancy, France.
CURRENT POSITION
Since 2017 – CNRS Research Engineer (IEHC)
PREVIOUS POSITION
2008-2017 – CNRS Research Engineer (IE1), UMR 8161 CNRS.
1998-2008 – CNRS Research Engineer (IE2), UMR 8527 CNRS.
SELECTION OF FIVE RECENT PUBLICATIONS
| 1 | Mouton, Stijn, Alexandra Mougel, Kirill Ustyantsev, Colette Dissous, Oleg Melnyk, Eugene Berezikov, et Jérôme Vicogne. « Optimized protocols for RNA interference in Macrostomum lignano ». G3 Genes|Genomes|Genetics 2024, 14, jkae037. https://doi.org/10.1093/g3journal/jkae037. Using our expertise in Schistosoma mansoni biology, we developed a cost-effective method for genetic interference in the flatworm Macrostomum lignano. |
| 2 | Nola, Giovanni de, Bérénice Leclercq, Alexandra Mougel, Solenne Taront, Claire Simonneau, Federico Forneris, Eric Adriaenssens, et al. « Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist ». Life Sci. Alliance 2022, 5: e202201424. https://doi.org/10.26508/lsa.202201424. Using combinations of chemical and structural biology approaches, we designed of a potent c-MET agonist with broad applications in regenerative medicine. |
| 3 | Mougel, Alexandra, Eric Adriaenssens, Boris Guyot, Lu Tian, Stéphanie Gobert, Thierry Chassat, Philippe Persoons, et al. « Macrophage-Colony-Stimulating Factor Receptor Enhances Prostate Cancer Cell Growth and Aggressiveness In Vitro and In Vivo and Increases Osteopontin Expression ». International Journal of Molecular Sciences 2022, 23: 16028. https://doi.org/10.3390/ijms232416028. |
| 4 | Leippe, P., J. Broichhagen, K. Cailliau, A. Mougel, M. Morel, C. Dissous, D. Trauner, et J. Vicogne. « Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors ». Angew. Chem. Int. Ed. 2020, 59: 6720‑23. https://doi.org/10.1002/anie.201915352. By mimicking the natural structure of the Venus Kinase Receptor and taking advantages photo-switchable glutamate ligands, we generate photo-activatable humanized tyrosine kinase chimeras. |
| 5 | Mekki, M. S., A. Mougel, A. Vinchent, C. Paquet, M. C. Copin, C. Leroy, Z. Kherrouche, et al. « Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors ». Oncotarget 2018, 9: 27039‑58. https://doi.org/10.18632/oncotarget.25472. |