publications
Protocol for oxalyl thioester (oxoSEA)-mediated protein modification
Francesco Terzani, F.; Wang, C.; Rostami, S.; Desmet, R.; Snella, B.; Sénéchal, M.; Wiltschi, B.; Vicogne, J.; Melnyk, O.; Agouridas, V. STAR protocols 2024, accepted
Peptide Alkyl Thioester Synthesis from Advanced Thiols and Peptide Hydrazides
Di Adamo, Julie, Nathalie Ollivier, Sonia Cantel, Vincent Diemer, et Oleg Melnyk. J. Org. Chem. 2024, in press.
Protein Desulfurization and Deselenization
Diemer, Vincent, Eliott Roy, Vangelis Agouridas, et Oleg Melnyk. Chem. Soc. Rev. 2024, 53, 8521‑45.
DOI: 10.1039/D4CS00135D.
Optimized protocols for RNA interference in Macrostomum lignano
Mouton, Stijn, Alexandra Mougel, Kirill Ustyantsev, Colette Dissous, Oleg Melnyk, Eugene Berezikov, et Jérôme Vicogne. G3 Genes|Genomes|Genetics 2024, 14, jkae037.
DOI: 10.1093/g3journal/jkae037
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus
Magali Casanova, Magali, Maresca, Marc, Poncin, Isabelle, Point, Vanessa, Olleik, Hamza, Boidin‑Wichlacz, Céline, Tasiemski, Aurélie, Mabrouk, Kamel, Cavalier, Jean‑François, Canaan, Stéphane. J. Biomed. Sci. 2024, 31, 18.
DOI: 10.1186/s12929-024-01007-8
A single coelomic cell type is involved in both immune and respiratory functions of the coastal bioindicator annelid: Capitella C-Channel1 from the English Channel
Boidin-Wichlacz, Céline, Andersen, Ann C., Jouy, Nathalie, Hourdez, Stéphane, Tasiemski, Aurélie. Developmental & Comparative Immunology 2024, 153, 105132.
An Iron-Catalyzed Protein Desulfurization Method Reminiscent of Aquatic Chemistry
Desmet, R.; Boidin-Wichlacz, C.; Mhidia, R.; Tasiemski, A.; Agouridas, O.; Melnyk, O. Angew. Chem. Int. Ed. 2023, 62, e202302648.
The diversification of the antimicrobial peptides from marine worms is driven by environmental conditions
Bruno, R.; Boidin-Wichlacz, C.; Melnyk, O.; Zeppilli, D.; Landon, C.; Thomas, F.; Cambon, M.-A.; Lafond, M.; Mabrouk, K.; Massol, F.; Hourdez, S.; Maresca, M.; Jollivet, D.; Tasiemski, A. STOTEN 2023, 879, 162875.
DOI: 10.1016/j.scitotenv.2023.162875
Electrostatic Assistance of 4-Mercaptophenylacetic acid catalyzed Native Chemical Ligation
Ollivier, N. ; Roy, E. ; Desmet, R. ; Agouridas, V.; Diemer, V.;Melnyk, O. Org. Lett. 2023, 25, 2696-2700.
DOI : 10.1021/acs.orglett.3c00796
Incorporation of a highly reactive oxalyl thioester-based interacting handle into proteins
Grain, B.; Desmet, R.; Snella, B.; Melnyk, O.; Agouridas, V. Org. Lett. 2023, 25, 5117-5122.
DOI: 10.1021/acs.orglett.3c01846
Pedal to the Metal: The Homogeneous Catalysis of the Native Chemical Ligation Reaction
Diemer, V.; Firstova, O.; Agouridas, V.; Melnyk, O. Chemistry 2022, 28, e202281662.
Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist
de Nola, G. ; Leclercq, B. ; Mougel, A. ;Taront, S. ;Simonneau, C. ;Forneris, F. ;Adriaenssens, E. ;Drobecq, H. ;Iamele, L. ;Dubuquoy, L.;Melnyk, O.; Gherardi, E.; de Jonge, H.;Vicogne, J. Life Sci. Alliance, 2022, 12, e202201424.
Thiol Catalysis of Selenosulfide Bond Cleavage by a Triarylphosphine
Firstova, O.; Melnyk, O.; Diemer, V. J. Org. Chem. 2022, 87, 9426–9430.
Fast Protein Modification in the Nanomolar Concentration Range Using an Oxalyl Amide as Latent Thioester
Snella, B. ; Grain, B. ; Vicogne, J ; Capet, F.; Wiltschi, B.; Melnyk, O.*; Agouridas, V.* Angew. Chem. Int. Ed. 2022, e202204992.
Redox-Controlled Chemical Protein Synthesis: Sundry Shades of Latency
Agouridas, V. ; Ollivier, N. ; Vicogne, J. ; Diemer, V.; Melnyk, O. Acc. Chem. Res. 2022, 55, 2685-2697.
DOI: 10.1021/acs.accounts.2c00436
Preview article. Protein Desulfurization: Sodium Tetraethylborate Makes It Fast
Diemer, V.; Melnyk, O. Chem 2022, 8, 2571-2573.
DOI: 10.1016/j.chempr.2022.09.011
A biomimetic electrostatic catalysis approach for guiding and promoting N-terminal protein chemical modification
Ollivier, N ; Sénéchal, M.; Desmet, R.; Snella, B.; Agouridas, V.; Melnyk, O. Nat. Commun. 2022, 13, N° 6667.
DOI: 10.1038/s41467-022-34392-5
A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells
Tauran, Y. ; Lereau-Bernier, M. ; Segard, B. D. ; Danoy, M. ; Kimura, K. ; Shinohara, M. ; Brioude, A. ; Sakai, Y. ; de Jonge, H. ; Melnyk, O. ; Vicogne, J. ; Leclerc, E. Dev Growth Differ. 2022, 64, 527-536.
DOI: 10.1111/dgd.12818
A Self-Purifying Microfluidic System for Identifying Drugs Acting Against Adult Schistosomes”
Girod, V. ; Ghoris, M.-J. ; Caby, S. ; Melnyk, O. ; Dissous, C. ; Senez, V. ; Vicogne, V.
Royal Society Open Science 2022, 9, N° 220648.
DOI: 10.1098/rsos.220648
Insights into the Mechanism and Catalysis of Peptide Thioester Synthesis by Alkylselenols Provide a New Tool for Chemical Protein Synthesis
Kerdraon, F.; Bogard, G.; Snella, B.; Drobecq, H.; Pichavant, M.; Agouridas, V.; Melnyk, O. Molecules 2021, 26, 1386.
DOI: 10.3390/molecules26051386
Strategies and open questions in solid phase protein chemical synthesis
Agouridas, V.; Diemer, V.; Melnyk, O. Curr. Opin. Chem. Biol. 2020, 58, 1-9.
DOI: 10.1016/j.cbpa.2020.02.007
Natural T cell epitope containing methyl-lysines on mycobacterial heparin-binding hemagglutinin
Corbière, V. ; Segers, J. ; Desmet, R. ; Lecher, S. ; Loyens, M. ; Petit, E. ; Melnyk, O. ; Locht, C. ; Mascart, F.
J. immunol. 2020, 1901214.
DOI : 10.4049/jimmunol.1901214
A cysteine selenosulfide redox switch for protein chemical synthesis
Diemer, V. ; Ollivier, N. ; Leclercq, B. ; Drobecq, H. ; Vicogne, J. ; Agouridas, V. ; Melnyk, O.
Nat. Commun., 2020, 11, 2558.
DOI : 10.1038/s41467-020-16359-6
Comment on « N-terminal Protein Tail Acts as Aggregation Protective Entropic Bristles : The SUMO Case
Sénéchal, M. ; Bouchenna, J. ; Vicogne, V. ; Melnyk, O. Biomacromolecules, 2020, 8, 3480-3482.
DOI : 10.1021/acs.biomac.0c00185
Catalysis of Hydrazone and Oxime Peptide Ligation by Arginine
Ollivier, N.; Agouridas, V.; Snella, B.; Desmet, R.; Drobecq, H.; Vicogne, J.; Melnyk, O. Org Lett 2020, 22, 8608-8612.
DOI : 10.1021/acs.orglett.0c03195
Chemical Protein Synthesis in Medicinal Chemistry
Agouridas, V.; El Mahdi, O.; Melnyk, O. J. Med. Chem. 2020, 63, 15140–15152.
DOI: 10.1021/acs.jmedchem.0c01082